Research Paper|Volume 10, Issue 2|pp 266—277

Four common polymorphisms of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk: evidence from 13,716 cancer patients and 15,590 cancer-free controls

Di Liu¹, Yi Zheng¹, Meng Wang¹, Yujiao Deng¹, Shuai Lin¹, Linghui Zhou¹, Pengtao Yang¹, Cong Dai¹, Peng Xu¹, Qian Hao¹, Dingli Song¹, Huafeng Kang¹, Zhijun Dai¹

¹Department of Oncology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China

* * Equal contribution

Received: January 14, 2018Accepted: February 9, 2018Published: February 16, 2018

https://doi.org/10.18632/aging.101388

Copyright: © 2018 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Previous studies have showed the associations between various BRCA1-interacting protein 1 (BRIP1) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population (P < 0.05). However, rs6504074 was associated with gynecologic cancer risk among overall population (P < 0.05). Further stratification analyses by ethnicity indicated that all 4 polymorphisms (rs2048718, rs4988344, rs4986764, and rs6504074) were strongly related to cancer susceptibility in Chinese people (P < 0.05). This meta-analysis showed that rs6504074 may play a decreased risk of gynecologic cancer in the overall population. Rs4988344, rs4986764, and rs6504074 were significantly related to decreasing cancer risk in Chinese population.