Brian H. Chen1,Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA2,Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA3Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA, Cara L. Carty4Division of Biostatistics and Study Methodology, Center for Translational Science, George Washington University and Children's National Medical Center, Washington, DC 20010, USA, Masayuki Kimura5Center of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA, Jeremy D. Kark6Epidemiology Unit, Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel, Wei Chen7Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA, Shengxu Li7Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA, Tao Zhang7Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA, Charles Kooperberg8Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Daniel Levy2,Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA3Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA, Themistocles Assimes9Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA, Devin Absher10HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA, Steve Horvath11,Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA12Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA, Alexander P. Reiner8,Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA13Department of Epidemiology, University of Washington, Seattle, WA 98195, USA, Abraham Aviv5Center of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA
- 1Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
- 2Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
- 3Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA
- 4Division of Biostatistics and Study Methodology, Center for Translational Science, George Washington University and Children's National Medical Center, Washington, DC 20010, USA
- 5Center of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA
- 6Epidemiology Unit, Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel
- 7Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70118, USA
- 8Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- 9Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
- 10HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
- 11Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
- 12Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA
- 13Department of Epidemiology, University of Washington, Seattle, WA 98195, USA
* * Equal contribution