Dan Ben-Avraham1Department of Medicine and Genetics Albert Einstein College of Medicine, Bronx, NY, 10461, USA, David Karasik2,Institute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02131, USA3Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel, Joe Verghese4Integrated Divisions of Cognitive & Motor Aging (Neurology) and Geriatrics (Medicine), Montefiore-Einstein Center for the Aging Brain, Albert Einstein College of Medicine, Bronx, NY, 10461, USA, Kathryn L. Lunetta5,The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA 01702, USA6Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA, Jennifer A. Smith7Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, John D. Eicher5,The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA 01702, USA8Population Sciences Branch, National Heart Lung and Blood Institute, Framingham, MA 01702, USA, Rotem Vered9Psychology Department, University of Haifa, Haifa, Israel, Joris Deelen10,Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands11Max Planck Institute for Biology of Ageing, Köln, Germany, Alice M. Arnold12Department of Biostatistics, University of Washington, Seattle, WA 98115, USA, Aron S. Buchman13Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60614, USA, Toshiko Tanaka14Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA, Jessica D. Faul15Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA, Maria Nethander16Bioinformatics Core Facility, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Myriam Fornage17The University of Texas Health Science Center at Houston, Houston, TX 77030, USA, Hieab H. Adams18,Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands19Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, Amy M. Matteini20Division of Geriatric Medicine, Johns Hopkins Medical Institutes, Baltimore, MD 21224, USA, Michele L. Callisaya21,Medicine, Peninsula Health, Peninsula Clinical School, Central Clinical School, Frankston, Melbourne, Victoria, Australia22Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia, Albert V. Smith23Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland, Lei Yu13Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60614, USA, Philip L. De Jager24Broad Institute of Harvard and MIT, Cambridge, Harvard Medical School, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA, Denis A. Evans25Rush Institute for Healthy Aging and Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA, Vilmundur Gudnason23Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland, Albert Hofman18,Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands26Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA, Alison Pattie27Department of Psychology, University of Edinburgh, Edinburgh, UK, Janie Corley27Department of Psychology, University of Edinburgh, Edinburgh, UK, Lenore J. Launer28Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA, Davis S. Knopman29Mayo Clinic, Rochester, MN 55905, USA, Neeta Parimi30California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA, Stephen T. Turner31Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA, Stefania Bandinelli32Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy, Marian Beekman10Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, Danielle Gutman48Department of Human Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel, Lital Sharvit48Department of Human Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel, Simon P. Mooijaart33Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherland, David C. Liewald34Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK, Jeanine J. Houwing-Duistermaat35Genetical Statistics, Leiden University Medical Center, Leiden, Netherland. Department of Statistics, University of Leeds, Leeds, UK, Claes Ohlsson36Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska, Academy, University of Gothenburg, Gothenburg, Sweden, Matthijs Moed10Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, Vincent J. Verlinden18Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands, Dan Mellström36Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska, Academy, University of Gothenburg, Gothenburg, Sweden, Jos N. van der Geest37Department of Neuroscience, Erasmus MC, Rotterdam, Netherlands, Magnus Karlsson38Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden, Dena Hernandez39Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA, Rebekah McWhirter22Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia, Yongmei Liu40Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC 27109, USA, Russell Thomson22,Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia41School of Computing, Engineering and Mathematics, University of Western Sydney, Sydney, Australia, Gregory J. Tranah30California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA, Andre G. Uitterlinden42Department of Internal Medicine, Erasmus MC, and Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands, David R. Weir15Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA, Wei Zhao7Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, John M. Starr34,Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK43Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK, Andrew D. Johnson5,The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA 01702, USA8Population Sciences Branch, National Heart Lung and Blood Institute, Framingham, MA 01702, USA, M. Arfan Ikram18,Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands19Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, David A. Bennett13Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60614, USA, Steven R. Cummings30California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA, Ian J. Deary27,Department of Psychology, University of Edinburgh, Edinburgh, UK34Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK, Tamara B. Harris28Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA, Sharon L. R. Kardia7Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Thomas H. Mosley44University of Mississippi Medical Center, Jackson, MS 39216, USA, Velandai K. Srikanth21,Medicine, Peninsula Health, Peninsula Clinical School, Central Clinical School, Frankston, Melbourne, Victoria, Australia22Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia, Beverly G. Windham44University of Mississippi Medical Center, Jackson, MS 39216, USA, Ann B. Newman45Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA, Jeremy D. Walston20Division of Geriatric Medicine, Johns Hopkins Medical Institutes, Baltimore, MD 21224, USA, Gail Davies27,Department of Psychology, University of Edinburgh, Edinburgh, UK34Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK, Daniel S. Evans30California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA, Eline P. Slagboom10Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, Luigi Ferrucci14Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA, Douglas P. Kiel2,Institute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02131, USA46Broad Institute of Harvard and MIT, Boston, MA 02131, USA, Joanne M. Murabito5,The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA 01702, USA47Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA, Gil Atzmon1,Department of Medicine and Genetics Albert Einstein College of Medicine, Bronx, NY, 10461, USA48Department of Human Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel
- 1Department of Medicine and Genetics Albert Einstein College of Medicine, Bronx, NY, 10461, USA
- 2Institute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02131, USA
- 3Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel
- 4Integrated Divisions of Cognitive & Motor Aging (Neurology) and Geriatrics (Medicine), Montefiore-Einstein Center for the Aging Brain, Albert Einstein College of Medicine, Bronx, NY, 10461, USA
- 5The National Heart Lung and Blood Institute’s Framingham Heart Study, Framingham, MA 01702, USA
- 6Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
- 7Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
- 8Population Sciences Branch, National Heart Lung and Blood Institute, Framingham, MA 01702, USA
- 9Psychology Department, University of Haifa, Haifa, Israel
- 10Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands
- 11Max Planck Institute for Biology of Ageing, Köln, Germany
- 12Department of Biostatistics, University of Washington, Seattle, WA 98115, USA
- 13Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60614, USA
- 14Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA
- 15Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104, USA
- 16Bioinformatics Core Facility, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
- 17The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
- 18Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
- 19Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands
- 20Division of Geriatric Medicine, Johns Hopkins Medical Institutes, Baltimore, MD 21224, USA
- 21Medicine, Peninsula Health, Peninsula Clinical School, Central Clinical School, Frankston, Melbourne, Victoria, Australia
- 22Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia
- 23Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
- 24Broad Institute of Harvard and MIT, Cambridge, Harvard Medical School, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA
- 25Rush Institute for Healthy Aging and Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA
- 26Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
- 27Department of Psychology, University of Edinburgh, Edinburgh, UK
- 28Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA
- 29Mayo Clinic, Rochester, MN 55905, USA
- 30California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA
- 31Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
- 32Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy
- 33Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherland
- 34Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
- 35Genetical Statistics, Leiden University Medical Center, Leiden, Netherland. Department of Statistics, University of Leeds, Leeds, UK
- 36Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska, Academy, University of Gothenburg, Gothenburg, Sweden
- 37Department of Neuroscience, Erasmus MC, Rotterdam, Netherlands
- 38Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden
- 39Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA
- 40Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC 27109, USA
- 41School of Computing, Engineering and Mathematics, University of Western Sydney, Sydney, Australia
- 42Department of Internal Medicine, Erasmus MC, and Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands
- 43Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK
- 44University of Mississippi Medical Center, Jackson, MS 39216, USA
- 45Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
- 46Broad Institute of Harvard and MIT, Boston, MA 02131, USA
- 47Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
- 48Department of Human Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel
* * Equal contribution
