Brian H. Chen1,Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA2,The NHLBI’s Framingham Heart Study, Framingham, MA 01702, USA3Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA, Riccardo E. Marioni4,Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK5,Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK6Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, Elena Colicino7Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA, Marjolein J. Peters8Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, 3000 CA, The Netherlands, Cavin K. Ward-Caviness9Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany, Pei-Chien Tsai10Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK, Nicholas S. Roetker11Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA, Allan C. Just7Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA, Ellen W. Demerath11Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA, Weihua Guan12Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, 55455, ; USA, Jan Bressler13Human Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX, ; USA, Myriam Fornage13,Human Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX, ; USA14Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, ; USA, Stephanie Studenski1Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, Amy R. Vandiver15Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, ; USA, Ann Zenobia Moore1Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, Toshiko Tanaka1Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, Douglas P. Kiel16,Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, ; USA17Institute for Aging Research, Hebrew Senior Life, Boston, MA 02215, USA, Liming Liang18,Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA19Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA, Pantel Vokonas18Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA, Joel Schwartz18Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA, Kathryn L. Lunetta2,The NHLBI’s Framingham Heart Study, Framingham, MA 01702, USA20Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA, Joanne M. Murabito2,The NHLBI’s Framingham Heart Study, Framingham, MA 01702, USA21Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA, Stefania Bandinelli22Geriatric Unit, Usl Centro Toscana Florence, Italy, Dena G. Hernandez23Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA, David Melzer24Epidemiology and Public Health, Medical School, University of Exeter, RILD, Exeter EX2 5DW, ; UK, Michael Nalls23Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA, Luke C. Pilling24Epidemiology and Public Health, Medical School, University of Exeter, RILD, Exeter EX2 5DW, ; UK, Timothy R. Price23Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA, Andrew B. Singleton23Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA, Christian Gieger9,Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany25Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany, Rolf Holle26Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, 85764 Neuherberg, Germany, Anja Kretschmer9,Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany25Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany, Florian Kronenberg27Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck 6020, Austria, Sonja Kunze9,Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany25Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany, Jakob Linseisen9Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany, Christine Meisinger9Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany, Wolfgang Rathmann28Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany, Melanie Waldenberger9,Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany25Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany, Peter M. Visscher4,Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK6,Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia29University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia, Sonia Shah6,Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia29University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia, Naomi R. Wray6Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia, Allan F. McRae6,Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia29University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia, Oscar H. Franco30Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, 3015 CN, The Netherlands, Albert Hofman18,Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA30Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, 3015 CN, The Netherlands, André G. Uitterlinden8,Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, 3000 CA, The Netherlands30Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, 3015 CN, The Netherlands, Devin Absher31HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA, Themistocles Assimes32Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, ; Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA, Morgan E. Levine33VA Palo Alto Health Care System, Palo Alto CA 94304, USA, Ake T. Lu33VA Palo Alto Health Care System, Palo Alto CA 94304, USA, Philip S. Tsao32,Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, ; Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA34Department of Preventive Medicine, Feinberg School of Medicine, Northwestern UniversityChicago, IL 60611, USA, Lifang Hou35,Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern UniversityChicago, IL 60611, USA36Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA, JoAnn E. Manson37Center for Translational Science Children’s National Medical Center, George Washington University, Washington, DC 20010, USA, Cara L. Carty38Department of Family Medicine and Public Health, University of California-San Diego, La Jolla, CA 92093-0725, ; USA, Andrea Z. LaCroix39Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA, Alexander P. Reiner40,Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, ; USA41Departments of Medicine, Molecular Biology/Genetics, Oncology, and Biostatistics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA, Tim D. Spector10Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK, Andrew P. Feinberg15,Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, ; USA42Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA, Daniel Levy2,The NHLBI’s Framingham Heart Study, Framingham, MA 01702, USA43Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA, Andrea Baccarelli7,Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA44Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK, Joyce van Meurs8Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, 3000 CA, The Netherlands, Jordana T. Bell10Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK, Annette Peters9Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany, Ian J. Deary4,Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK45Department of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA, James S. Pankow11Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA, Luigi Ferrucci1Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, Steve Horvath33,VA Palo Alto Health Care System, Palo Alto CA 94304, USA45Department of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA
- 1Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
- 2The NHLBI’s Framingham Heart Study, Framingham, MA 01702, USA
- 3Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA
- 4Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
- 5Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK
- 6Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia
- 7Laboratory of Environmental Epigenetics, Departments of Environmental Health Sciences and Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA
- 8Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, 3000 CA, The Netherlands
- 9Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany
- 10Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK
- 11Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA
- 12Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN, 55455, ; USA
- 13Human Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX, ; USA
- 14Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, ; USA
- 15Center for Epigenetics, Johns Hopkins University, Baltimore, MD 21205, ; USA
- 16Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, ; USA
- 17Institute for Aging Research, Hebrew Senior Life, Boston, MA 02215, USA
- 18Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
- 19Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
- 20Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA
- 21Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
- 22Geriatric Unit, Usl Centro Toscana Florence, Italy
- 23Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20814, USA
- 24Epidemiology and Public Health, Medical School, University of Exeter, RILD, Exeter EX2 5DW, ; UK
- 25Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany
- 26Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, 85764 Neuherberg, Germany
- 27Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck 6020, Austria
- 28Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, 40225 Düsseldorf, Germany
- 29University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia
- 30Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, 3015 CN, The Netherlands
- 31HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
- 32Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, ; Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
- 33VA Palo Alto Health Care System, Palo Alto CA 94304, USA
- 34Department of Preventive Medicine, Feinberg School of Medicine, Northwestern UniversityChicago, IL 60611, USA
- 35Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern UniversityChicago, IL 60611, USA
- 36Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA
- 37Center for Translational Science Children’s National Medical Center, George Washington University, Washington, DC 20010, USA
- 38Department of Family Medicine and Public Health, University of California-San Diego, La Jolla, CA 92093-0725, ; USA
- 39Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA
- 40Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, ; USA
- 41Departments of Medicine, Molecular Biology/Genetics, Oncology, and Biostatistics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
- 42Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 01702, USA
- 43Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
- 44Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
- 45Department of Biostatistics, School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA
* * Equal contribution
