Research Paper Volume 6, Issue 1 pp 9—25
Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity
- 1 NESTEC SA, Nestlé Research Center, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland
- 2 Nestlé Institute of Health Sciences SA, Campus EPFL, Molecular Biomarkers Core, Quartier de l'innovation, CH-1015 Lausanne, Switzerland
- 3 Department of Medical Sciences, University of Milan, Milan, Italy
- 4 Geriatric Unit IRCCS Ca' Grande Foundation Maggiore Policlinico Hospital, Milan, Italy
- 5 Department of Experimental, Diagnostic and Specialty Medicine Experimental Pathology, University of Bologna, Via S. Giacomo 12, 40126 Bologna, Italy
- 6 Interdepartmental Centre “L. Galvani” CIG, University of Bologna, Piazza di Porta S. Donato 1, 40126 Bologna, Italy
- 7 Department of Clinical, Experimental and Biomedical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
- 8 Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
- 9 Faculty of Life Sciences, Ecole Polytechnique Fédérale Lausanne (EPFL), Lausanne, Switzerland
- 10 Faculty of Science, Interdisciplinary NanoScience Center (iNANO), Aarhus University, Aarhus, Denmark
Received: December 5, 2013 Accepted: January 19, 2014 Published: January 21, 2014
https://doi.org/10.18632/aging.100630How to Cite
Abstract
As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.