Figure 3 — Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring

Research Paper|Volume 17, Issue 12|pp. 2950–2988

Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring

Back to articleFigure 3(3 of 9)

100%

Figure 3.Chromosomal distribution of age-associated DMCs in sperm. Miami plot of age-associated differentially methylated CpG sites (DMCs), shown by direction of change (Delta β >0 relates to an increase in number of sperm cells that are methylated, Delta β <0 means a decrease in number of sperm cells that are methylated). Dashed line: no change (Δβ = 0). Delta β-values are calculated from M-values, as shown in the methods section

(Δβ = \frac{2^{(M_{0} + delta M)}}{1 + 2^{(M_{0} + delta M)}} - \frac{2^{M_{0}}}{1 + 2^{M_{0}}})

. Significant DMCs correspond to FDR <0.05. Blue dots are sites allocated to imprinted genes, listed in the Geneimprint database.