Figure 2 — Blood vessel and osteocyte networks concurrently rearrange during bone maturation and decline during aging in the femur of male mice

Research Paper|Volume 17, Issue 8|pp. 2089–2112

Blood vessel and osteocyte networks concurrently rearrange during bone maturation and decline during aging in the femur of male mice

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Figure 2.Blood vessel (BVs) network characterization. (A) GFP⁺ (green) blood vessels in growing, mature, middle-aged and aged femurs, scale bar = 200 μm. (B) Categorization of the branched vessels used for quantification. (C) Correlation between the number of GFP⁺ BVs per bone volume and age (months). (D) Correlation between the percentage of volume of BVs per mm³ of cortical bone and age (months). (E) Lectin⁺ (cyan) blood vessels in cortical bone in growing, mature, middle-aged and aged femurs. ^* indicates the blood vessel location. The dashed lines delineate bone. Statistical analyses: Spearman’s correlation.