Figure 5 — Sesn-1 is required for lifespan extension during caloric deprivation in C. elegans through inhibition of mTORC1 and activation of autophagy

Research Paper|Volume 17, Issue 7|pp. 1834–1851

Sesn-1 is required for lifespan extension during caloric deprivation in C. elegans through inhibition of mTORC1 and activation of autophagy

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Figure 5.Autophagy intensity in C. elegans is influenced by sesn-1 and npp-18, a component of the GATOR2 complex. Control adIs2122 and adIs2122; sesn-1(RNAi) nematodes expressing GFP::LGG-1, with or without simultaneous npp-18 knockdown by RNAi, were subjected to starvation. The relative levels of GFP::LGG-1 conjugation to autophagosomes were measured by immunoblot densitometry. All bar graphs represent blot intensity normalized to actin.