Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet

Naidu B. Ommi; Dwight A.L. Mattocks; Karel Kaleck&#xfd;; Teodoro Bottiglieri; Sailendra N. Nichenametla

doi:doi:10.18632/aging.206237

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Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet

Figure 6. BSO decreases the mRNA expression of lipogenic but not lipolytic genes. Similar to the SAAR diet, BSO decreased the mRNA expression of lipogenic genes, including Scd1 (A), Gpam (B), Mogat1 (C), and Mogat2 (D). The SAAR diet, but not BSO, increased the mRNA expression of lipolytic genes like Atgl (E), Ppargc1a (F), Arl8b (G), and Hadhb (H). NAC reversed the effects of the SAAR diet on all these genes. Note: Statistical methods are similar to those in Figure 2. Sample size is as mentioned in Figure 1.