Research Paper Advance Articles

Figure 2. BSO decreases tissue concentrations of cysteine and glutathione, but not of methionine. Similar to the SAAR diet, BSO decreased total cysteine (tCys) (A) and total glutathione (tGSH) (B) in the liver, but to a lower extent. Unlike the SAAR diet, which did not alter hepatic methionine, BSO increased it (C). BSO exerted stronger effects than the SAAR diet on tCys (D) and tGSH (E) in the kidney. The SAAR diet, but not BSO, decreased methionine in the kidney (F). NAC reversed the impact of the SAAR diet on both sulfur compounds. Note: # indicates P-values from a 2-tailed Student’s t-test; the rest of the statistical methods are similar to those in Figure 1.