Research Paper Volume 17, Issue 3 pp 610—629
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
Figure 4. Excessive mitochondrial ROS in osteoblast lineage does not impact load-induced bone formation. Histomorphometric measurements at the periosteal (A) and endosteal (B) tibial surface at 5 mm proximal from the tibiofibular junction of the right (non-loaded) and left (loaded) tibia from Osx1-Cre (n=7) and Sod2ΔOsx1 (n=8) female mice, and (C) representative photomicrographic cross-section images. Scale bar, 200 μm. Bars represent mean ± SD. Data analyzed using two-way mixed ANOVA; p-values adjusted by Holm-Sidak’s test. Int: Interaction; Gen: Genotype.