Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model

Hoang Van M. Nguyen; Eleana Cabello; David Dyer; Chloe Fender; Manuel Garcia-Jaramillo; Norman G. Hord; Steven Austad; Arlan Richardson; Archana Unnikrishnan

doi:doi:10.18632/aging.206211

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Research Paper Volume 17, Issue 2 pp 524—549

Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model

Figure 4. The mt-haplotype affects several microbe groups in OKCHET^B/W rats. Microbial OTUs are compared for OKC-HET^B (blue boxes) and OKC-HET^W (red boxes) male (A) and female (B) rats. The box plots display the 1st and 3rd quartiles with a horizontal line the median. The whiskers display minimum and maximum values. The data were collected from 6 to 10 rats per group, and the mt-haplotypes were statistically compared using Mann-Whitney/Kruskal-Wallis and/or Linear Modeling with significance at ^*p < 0.05 or ^**p < 0.01 shown.