Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model

Hoang Van M. Nguyen; Eleana Cabello; David Dyer; Chloe Fender; Manuel Garcia-Jaramillo; Norman G. Hord; Steven Austad; Arlan Richardson; Archana Unnikrishnan

doi:doi:10.18632/aging.206211

← Back

Research Paper Volume 17, Issue 2 pp 524—549

Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model

Figure 2. Beta-diversity is different with age in OKC-HET^B/W rats. Beta-diversity of the microbiome was measured using Jenssen-Shannon divergence comparing adult (9-months, blue ovals) and old (26-months, red ovals) rats for the following: male OKC-HET^B (A), male OKC-HET^W (B), female OKC-HET^B (C), and female OKC-HET^W (D) rats. Beta-diversity was also compared between OKC-HET^B (blue ovals) and OKC-HET^W (red ovals) haplotypes for the following: adult male (E), old male (F), adult female (G), and old female (H) rats. Oval outlines represent the 95% confidence interval for each group. The data were collected from 6 to 10 rats per group, and those values statistically significant by PERMANOVA at ^*p < 0.05 or ^**p < 0.01 are shown.