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Identification of senescence rejuvenation mechanism of Magnolia officinalis extract including honokiol as a core ingredient

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Figure 4. M. officinalis extract enhances skin barrier function by increasing skin regeneration and suppressing skin inflammation. (A) The expression levels of the SLIT2 in senescent fibroblasts were assessed after 12 days of treatment with DMSO (0.01%) or M. officinalis extract (0.625 μg/ml). Young fibroblasts were used as a positive control. **P < 0.01, Student’s t–test. Means ± S.D., N = 3. (B) The expression levels of the COL1A1 in senescent fibroblasts were assessed after 12 days of treatment with DMSO (0.01%) or M. officinalis extract (0.625 μg/ml). Young fibroblasts were used as a positive control. ***P < 0.001, Student’s t–test. Means ± S.D., N = 3. (C) The expression levels of the MMP1 in senescent fibroblasts were assessed after 12 days of treatment with DMSO (0.01%) or M. officinalis extract (0.625 μg/ml). Young fibroblasts were used as a positive control. ***P < 0.001, Student’s t–test. Means ± S.D., N = 3. (D) The expression levels of the CCL2 in senescent fibroblasts were assessed after 12 days of treatment with DMSO (0.01%) or M. officinalis extract (0.625 μg/ml). Young fibroblasts were used as a positive control. ***P < 0.001, Student’s t–test. Means ± S.D., N = 3. (E) The expression levels of the CCL5 in senescent fibroblasts were assessed after 12 days of treatment with DMSO (0.01%) or M. officinalis extract (0.625 μg/ml). Young fibroblasts were used as a positive control. ***P < 0.001, Student’s t–test. Means ± S.D., N = 3. (F) The expression levels of the IL–6 in senescent fibroblasts were assessed after 12 days of treatment with DMSO (0.01%) or M. officinalis extract (0.625 μg/ml). Young fibroblasts were used as a positive control. ***P < 0.001, Student’s t–test. Means ± S.D., N = 3. (G) The expression levels of the IL–8 in senescent fibroblasts were assessed after 12 days of treatment with DMSO (0.01%) or M. officinalis extract (0.625 μg/ml). **P < 0.01, Student’s t–test. Mean ± S.D., N = 3. Young fibroblasts were used as a positive control. **P < 0.01, ***P < 0.001, Student’s t–test. Means ± S.D., N = 3.