Research Paper Advance Articles
Chronic β3 adrenergic agonist treatment improves neurovascular coupling responses, attenuates blood-brain barrier leakage and neuroinflammation, and enhances cognition in aged mice
Figure 3. Effects of chronic β3-AR treatment on cognitive performance in aged mice. (A) Radial arm water maze- Heatmap showing an animal from each group that was chosen at random and the amount of time they spent in different arms and also the traces indicating the path the mice took to reach the target. Please take note that the aged controls took longer paths and made more errors in finding the target platform when compared to the CL-treated mice. (B) Cumulative errors calculated during the learning, probe, and reversal trials. (C) Time to escape calculated during each of the learning, probe and reversal day trials and (D). Swim speed (cm/s) in radial arm water maze test (n = 6–10/group, both sexes). Data are mean ± S.E.M. *P < 0.05 vs. aged controls, ns-not significant.