Priority Research Paper Volume 16, Issue 22 pp 13452—13504

Figure 5. Neuron and glia specific clocks predict age-acceleration in AD. (A) Forest plot of associations between DNAmAge and Alzheimer’s Disease (AD) for 6 different epigenetic clocks across 5 independent DNAm datasets from frontal lobe (FL) or prefrontal cortex (PFC). The effect sizes and P-values of a fixed and random effects models are also given. Statistics and P-values of heterogeneity are shown above each panel. Number of samples in each dataset is given to the left. (B) As (A) but for DNAm datasets profiling regions in the temporal lobe (TL), which includes middle and superior temporal gyrus (MTG and STG). (C) As (A), but combing FL and TL regions.