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Research Paper Advance Articles

Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice

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Figure 5. Effect of ABT-263 on SASP factor expression in the 28Si-exposed Apc1638N/+ mice serum. (A) Principal component analysis (PCA) plot for cytokines showing differential expression. (B) Heat map showing differential expression of SASP factor expression in serum obtained from vehicle, 28Si + vehicle, and 28Si + ABT-263 groups. (C) Fold change in serum TNFRSF1B. (D) Fold change in serum CCL20. (E) Fold change in serum CXCL4. (F) Fold change in serum P-selectin. (G) Fold change in serum CCL27. (H) Fold change in serum CXCL16. Quantitative data presented as mean ± SEM, and * depict a statistically significant difference (p<0.05) between the indicated groups.