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Research Paper Advance Articles

Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice

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Figure 3. ABT-263 eliminates SASP cells from the intestinal epithelium of γ-exposed Apc1638N/+ mice. (A) Representative immunofluorescence micrographs of the intestinal epithelium showing p16 (red) and IL6 (green) dual-positive cells. (B) Quantification of p16 and IL6 dual-positive cells. Data presented as mean ± SEM, and * p<0.05, relative to control animals.