Research Paper Advance Articles
DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility
Figure 3. Distribution of DNAmAge (A–C) and cancer-free probability curve of IEAA (D–F) by BC status and BC subtype. (IEAA, intrinsic epigenetic age acceleration as residuals adjusted for cell composition; ACC, acceleration, i.e., positive residuals; BC, breast cancer; DCC, deceleration, i.e., negative residuals; DNAmAge, DNA methylation–based marker of aging; ER/PR, estrogen and progesterone receptor; HER2/neu, human epidermal growth factor receptor 2). (A) DNAmAge, BC (B) DNAmAge, ER/PR Status (C) DNAmAge, HER2/neu Status (D) IEAA, BC (E) IEAA, ER/PR positive (F) IEAA, HER2/neu negative.