Supplementation with nicotinamide limits accelerated aging in affected individuals with cockayne syndrome and restores antioxidant defenses

Asma Chikhaoui; Kouloud Zayoud; Ichraf Kraoua; Sami Bouchoucha; Anis Tebourbi; Ilhem Turki; Houda Yacoub-Youssef

doi:doi:10.18632/aging.206160

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Research Paper Volume 16, Issue 21 pp 13271—13287

Supplementation with nicotinamide limits accelerated aging in affected individuals with cockayne syndrome and restores antioxidant defenses

Figure 3. The level of oxidative stress-related gene expression after nicotinamide stimulation. The histograms represent fold-changes in genes up-or downregulated in CS-A, CS-B, elderly group and young healthy donors’ group normalized to non-treated control conditions of each group. (A) PRDX3, (B) FOXM1, (C) NQO1 and (D) ALOX12.