Research Paper Volume 16, Issue 21 pp 13252—13270

Figure 6. ASCs-derived extracellular vesicles exert a therapeutic effect in OA mice. (A) Histological OA score determined at different time points in collagenase-induced osteoarthritis (CIOA) mice (left panel). Representative pictures of histological sections from each group of mice at day 42 (n = 5/group). (B) Relative expression of genes representative of senescence, inflammation, oxidative stress and metabolism in the joints of CIOA mice (n = 6, 7/group). Data are shown as mean ± SEM. Statistical analysis used Kruskall-Wallis test with a Dunn’s post-test. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.