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Research Paper Volume 16, Issue 21 pp 13225—13236

Adolescents and young adults with sickle cell disease exhibit accelerated aging with elevated T-cell p16INK4a expression

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Figure 1. Expression of PBTL p16INK4a in AYAs with SCD. (A) Mean p16 expression in AYAs with SCD (10.1 log2 p16 units) is significantly elevated compared to those without SCD (8.7 log2 p16 units), p < 0.001. (B) Expression of p16 in individuals with SCD did not differ by chronic transfusion therapy (CTT) status.