Research Paper Advance Articles
Upregulation of multiple key molecules is correlated with poor prognosis and immune infiltrates in hepatocellular carcinoma by bulk and single-cell RNA-seq
Figure 3. Identification of key molecules in LIHC. (A) Venn diagram visualizing the intersections of DEGs with KM analysis. (B) Construction of a protein–protein interaction (PPI) network among differentially expressed genes. (C) The relationship among the ten key molecules at the protein level. (D) Volcano plot constructed with the cut-off criterion p < 0.05 and |logFC|≥ 1. Red, up-regulated genes; Green, down-regulated genes. The circle represented each gene and the identified key molecules were marked. (E) Principal component analysis for the key molecules revealed two completely disjoint populations, suggesting these key molecules could well distinguish LIHC samples from normal samples. Blue, normal samples; Red, tumor samples.