Research Paper Volume 16, Issue 20 pp 13039—13075

Figure 11. A summary of the localization and protein levels of canonically active EphA2-pY589 and non-canonically active EphA2-pS898 in control and ephrin-A5^-/- lenses from 6-week-old, 4-month-old, and 8-month-old mice. Canonical ligand-mediated EphA2-pY589 is only found in lens epithelial cells, and protein levels do not change with age. Non-canonical ligand-independent activation of EphA2-pS898 is found in epithelial cells and mature fiber cells in the lens cortex. The levels of EphA2-pS898 increase with age, and in ephrin-A5^-/- epithelial cells, there is an increase compared to the control in 8-month-old mice. Cartoon not drawn to scale. Modified from [38].