Research Paper Volume 16, Issue 21 pp 13323—13339
A differentially-methylated-region signature predicts the recurrence risk for patients with early stage lung adenocarcinoma
Figure 3. Construction of a 15-DMR prognostic signature in the model training cohort. (A) LASSO penalized Cox regression analysis yielded 15 DMRs for the recurrence risk predicting model construction. (B) Hazard ratio with 95% confidence interval (CI) and P-value of the 15 DMRs in the univariable Cox regression analysis for disease-free survival (DFS). (C) Heatmap of the methylation value of the 15 DMRs in low-risk (n = 45) and high-risk (n = 72) groups. (D) Kaplan-Meier (KM) curves for DFS in the model training cohort. (E) Time-dependent receiver operating characteristic (ROC) curves in the model training cohort. (F) Comparison of the risk score in the different clinical subgroups including age, sex, smoking history, and TNM stage.