Research Paper Volume 16, Issue 19 pp 12685—12696
Use of the senolytics dasatinib and quercetin for prevention of pelvic organ prolapse in a mouse animal model
Figure 1. Impact of serial dasatinib and quercetin (D+Q) injections on development of pelvic organ prolapse in wild type (WT) and Fibulin-5 knockout (Fbln-5-/-) mice. D+Q or placebo injections were administered at weeks 4, 5, 6, 7 and 8 of life to treatment and control groups, respectively. Mouse pelvic organ prolapse quantification measurements were used to obtain weekly perineal body length (A) and vaginal bulge height (B) values. WT control (n=27), WT treatment (n=27), Fbln-5-/- control (n=33), Fbln-5-/- treatment (n=30). p <0.05 between Fbln-5-/- treatment mice and Fbln-5-/- control mice, and between Fbln-5-/- treatment mice and WT treatment mice (A).