Research Paper Volume 16, Issue 18 pp 12651—12666

Figure 6. Analysis of RNA sequencing data demonstrated distinct gene expression pattern between replicative senescent dermal fibroblasts and senescent reversed immortalized keratinocytes. (A, B) Gene expression heatmaps illustrating the expression profiles of gene sets previously identified as upregulated and downregulated in senescent dermal fibroblasts, according to data from GSE63577. (C) GSEA results depicting the enrichment of DEGs between PBS and Dox group of reversibly immortalized keratinocytes in gene sets from GSE63577 dataset. (D) Gene expression heatmap showing the expression of the SASP-related gene set in senescent fibroblasts from the GSE63577 dataset. (E) GSEA result of the enrichment of DEGs from the GSE63577 dataset in the SASP-related gene set.