Research Paper Volume 16, Issue 19 pp 12866—12892
DNA methylation-driven gene FAM3D promotes colorectal cancer growth via the ATF4-SESN2-mTORC1 pathway
Figure 7. FAM3D functions in CRC cells by targeting SESN2 and activating the mTORC1 pathway. (A) The migration and invasion of FAM3D-knockout LoVo cells with SESN2 knockdown. (B) The migration and invasion of FAM3D-overexpressing LoVo cells with SESN2 overexpression. (C) Western blot analysis of FAM3D-knockout LoVo cells with SESN2 knockdown. (D) Western blot analysis of FAM3D-overexpressing LoVo cells with SESN2 overexpression. ****P < 0.0001.