Research Paper Volume 16, Issue 18 pp 12608—12622
Characterization of a ferroptosis-related gene signature predicting survival and immunotherapeutic response in lung adenocarcinoma
Figure 1. Establishment of the prognostic ferroptosis-related gene signature. (A) Volcano plot showed differentially expressed genes in lung adenocarcinoma. Blue dots represent downregulated genes, red dots represent upregulated genes, and grey dots represent unchanged genes. (B) There were 20 overlapping genes among 20205 DEGs, 5905 prognostically relevant genes, and 259 ferroptosis genes. (C) 11 eligible genes were obtained in the univariate Cox regression model. (D, E) Seven genes (RRM2, IL33, SLC2A1, PEBP1, DDIT4, VDAC2, and FLT3) were acquired in LASSO regression model.