Research Paper Volume 16, Issue 18 pp 12559—12573
The joint protective function of live- and dead-Lactobacillus plantarum GKD7 on anterior cruciate ligament transection induces osteoarthritis
Figure 5. Administration of GKD7-L and GKD7-D reduced levels of TNF-α and IL-1β expression on synovial tissue. (A) IHC staining of TNF-α and IL-1β expression in a representative synovial tissue sample from the control, OA, OA+GKD7-L (25 mg/kg), OA+GKD7-L (100 mg/kg), and OA+GKD7-D (100 mg/kg) groups. Quantitative evaluations of cartilage’s TNF-α and IL-1β (B, C). Values are presented as the mean ± SD for each group. Scale bar = 100 µm. *p < 0.05 versus controls; #p < 0.05 versus the OA group.