The joint protective function of live- and dead-<i>Lactobacillus plantarum</i> GKD7 on anterior cruciate ligament transection induces osteoarthritis

Yen-You Lin; Chih-Ying, Wu; You-Shan Tsai; Chin-Chu Chen; Tzu-Ching Chang; Li-Chai Chen; Hsien-Te Chen; Chin-Jung Hsu; Chih-Hsin Tang

doi:doi:10.18632/aging.206101

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Research Paper Volume 16, Issue 18 pp 12559—12573

The joint protective function of live- and dead-Lactobacillus plantarum GKD7 on anterior cruciate ligament transection induces osteoarthritis

Figure 3. Therapeutic effects of GKD7 treatment evaluated by micro-CT. (A) Rat knee coronal and transverse micro-CT investigates from the control, OA, OA +GKD7-L (25 mg/kg), OA +GKD7-L (100 mg/kg), and OA +GKD7-D (100 mg/kg) groups. (B–H) Quantitative evaluations of bone surface/total volume (BS/TV), bone volume/total volume (BV/TV), bone mineral density (BMD), bone mineral content (BMC), bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp). The red arrows indicate bone erosion. ^*p < 0.05 in comparison to the controls; ^#p < 0.05 in comparison to the OA group.