Research Paper Volume 16, Issue 17 pp 12312—12334

Identification of a circadian-based prognostic signature predicting cancer-associated fibroblasts infiltration and immunotherapy response in bladder cancer

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Figure 10. Correlation analysis of FAM20C and TBX1 with the immunosuppressive microenvironment. (A) Correlation of FAM20C or (B) TBX1 expression with infiltration of CAFs. The CAFs were estimated by EPIC, XCELL, MCPcounter and TIDE. (C, D) Kaplan-Meier plot of different groups as indicated. (E) Correlation of FAM20C or (F) TBX1 with exhausted T-cell and effector Treg cells. Exhausted T-cell signatures: HAVCR2, TIGIT, LAG3, PDCD1, CXCL13, LAYN; effector Treg cell signatures: FOXP3, CTLA4, CCR8, TNFRSF9.