Research Paper Volume 16, Issue 16 pp 11904—11916
Downregulating miR-432-5p exacerbates adriamycin-induced cardiotoxicity via activating the RTN3 signaling pathway
Figure 4. miR-432-5p alleviates ADR-induced toxicity in mice. (A) The body weight change after ADR-treated mice received miR-432-5p; (B) The LVEF improves after miR-432-5p treatment; (C) Improved LVSF after miR-432-5p treatment; (D) The activity of ATP synthesis in mouse myocardial tissue; The immunohistochemical images (E). Results showed the injury caused by ADR was improved by miR-432-5p; (F) The protein expressions of LC3B, cleaved-caspase 3, Beclin 1, RTN3, and CHOP decreased in ADR stimulated cells pretreated by miR-432-5p. *p < 0.05, **p < 0.01, ***p < 0.001.