Downregulating miR-432-5p exacerbates adriamycin-induced cardiotoxicity via activating the RTN3 signaling pathway

Wei Geng; Shaohua Yan; Dasen Sang; Jie Tao; Xuefei Zhang; Xinshun Gu; Xiangyu Zhang

doi:doi:10.18632/aging.206062

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Research Paper Volume 16, Issue 16 pp 11904—11916

Downregulating miR-432-5p exacerbates adriamycin-induced cardiotoxicity via activating the RTN3 signaling pathway

Figure 3. RTN3 activation in ADR-treated cardiomyocytes. (A) The decreasing ATPase activity in cardiomyocytes; (B) The expression of LC3B, cleaved-caspase 3, Beclin 1, RTN3, and CHOP protein increased in ADR-treated myocardium; (C) The binding site between RTN3 and miR-432-5p; (D) The binding of RTN3 and miR-432-5p is verified by luciferase report gene. ^**p < 0.01, ^***p < 0.001.