Acyl-CoA thioesterase 13 (<i>ACOT13</i>) attenuates the progression of autosomal dominant polycystic kidney disease <i>in vitro</i> via triggering mitochondrial-related cell apoptosis

Bin Wang; Qi Yang; Lihe Che; Luyao Sun; Na Du

doi:doi:10.18632/aging.206054

← Back

Research Paper Volume 16, Issue 16 pp 11877—11892

Acyl-CoA thioesterase 13 (ACOT13) attenuates the progression of autosomal dominant polycystic kidney disease in vitro via triggering mitochondrial-related cell apoptosis

Figure 6. ACOT13 overexpression induced mitochondria damage in WT9-12 cells. WT9-12 cells were transfected with ACOT13 OE plasmids. (A) The ATP concentration in cells were detected using an ELISA kit. (B) JC-1 staining was performed to evaluate the MMP level (the ratio of red/green fluorescence intensity) in WT9-12 cells (magnification, 200×). ***P<0.001 vs. control group.