Acyl-CoA thioesterase 13 (<i>ACOT13</i>) attenuates the progression of autosomal dominant polycystic kidney disease <i>in vitro</i> via triggering mitochondrial-related cell apoptosis

Bin Wang; Qi Yang; Lihe Che; Luyao Sun; Na Du

doi:doi:10.18632/aging.206054

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Research Paper Volume 16, Issue 16 pp 11877—11892

Acyl-CoA thioesterase 13 (ACOT13) attenuates the progression of autosomal dominant polycystic kidney disease in vitro via triggering mitochondrial-related cell apoptosis

Figure 3. ACOT13 was downregulated in WT9-12 cells. (A) RT-qPCR was used to determine ACOT13 mRNA level in HK-2 and WT9-12 cells. **P<0.01 vs. HK-2 group. (B) Western blot assays were applied to assess ACOT13 protein level in HK-2 and WT9-12 cells. **P<0.01 vs. HK-2 group. (C) RT-qPCR was used to determine ACOT13 mRNA level in WT9-12 cells transfected with ACOT13 OE plasmids. ***P<0.001 vs. control group. (D) Western blot assays were applied to assess ACOT13 protein level in WT9-12 cells transfected with ACOT13 OE plasmids. ***P<0.001 vs. control group.