Acyl-CoA thioesterase 13 (<i>ACOT13</i>) attenuates the progression of autosomal dominant polycystic kidney disease <i>in vitro</i> via triggering mitochondrial-related cell apoptosis

Bin Wang; Qi Yang; Lihe Che; Luyao Sun; Na Du

doi:doi:10.18632/aging.206054

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Research Paper Volume 16, Issue 16 pp 11877—11892

Acyl-CoA thioesterase 13 (ACOT13) attenuates the progression of autosomal dominant polycystic kidney disease in vitro via triggering mitochondrial-related cell apoptosis

Figure 2. The relationship between ACOT13 and mitochondria-associated genes (Mito-RGs) in ADPKD. (A) The common genes (mitochondria-related DEGs) between DEGs and mitochondria-associated genes were screened by Venn. (B) Heatmap showed the mitochondria-related DEGs between H- and L-ACOT13 groups. Blue color represents downregulated genes; red color indicates upregulated genes. (C) GO analysis including top 10 BP, top 10 CC and top 10 MF terms. (D) Top 20 KEGG pathways.