Figure 1. ACOT13 was reduced in renal cystic tissues. (A) The box plot showed the ACOT13 level in normal and ADPKD tissues in the GSE7869 dataset. (B) The volcano plot displayed DEGs between H- and L-ACOT13 groups. Blue color represents downregulated genes; red color indicates upregulated genes. (C) GO analysis including top 10 BP, top 10 CC and top 10 MF terms. (D) Top 20 KEGG pathways. (E) Enrichment of genes in the MAPK signaling pathway and PI3K-AKT signaling pathway by GSEA. (F) Enrichment of genes in the fatty acid metabolism, oxidative phosphorylation and PPAR signaling pathway by GSEA.