Acyl-CoA thioesterase 13 (<i>ACOT13</i>) attenuates the progression of autosomal dominant polycystic kidney disease <i>in vitro</i> via triggering mitochondrial-related cell apoptosis

Bin Wang; Qi Yang; Lihe Che; Luyao Sun; Na Du

doi:doi:10.18632/aging.206054

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Research Paper Volume 16, Issue 16 pp 11877—11892

Acyl-CoA thioesterase 13 (ACOT13) attenuates the progression of autosomal dominant polycystic kidney disease in vitro via triggering mitochondrial-related cell apoptosis

Figure 1. ACOT13 was reduced in renal cystic tissues. (A) The box plot showed the ACOT13 level in normal and ADPKD tissues in the GSE7869 dataset. (B) The volcano plot displayed DEGs between H- and L-ACOT13 groups. Blue color represents downregulated genes; red color indicates upregulated genes. (C) GO analysis including top 10 BP, top 10 CC and top 10 MF terms. (D) Top 20 KEGG pathways. (E) Enrichment of genes in the MAPK signaling pathway and PI3K-AKT signaling pathway by GSEA. (F) Enrichment of genes in the fatty acid metabolism, oxidative phosphorylation and PPAR signaling pathway by GSEA.