Research Paper Volume 16, Issue 15 pp 11568—11576
Circular RNA circMRPS35 represses malignant progression in osteosarcoma cells via targeting miR-105-5p/FOXO1
Figure 1. The overexpression of circMRPS35 inhibits cell proliferation of osteosarcoma in vitro and in vivo. (A–D) The MG63 and MNNG/HOS cells were treated with circMRPS35 overexpressing plasmid. (A, B) The expression of circMRPS35 was detected by qPCR. (C, D) The cell viability was measured by CCK-8 assay. (E–G) The tumorigenesis analysis was performed in nude mice injected with MG63 cells treated with circMRPS35 overexpressing plasmid. **P < 0.01.