Research Paper
Ginsenoside Rh4 reverses ABCB1-induced doxorubicin resistance via the PI3Kδ/AKT axis in osteosarcoma
Figure 3. Impact of ginsenoside Rh4 on MG63/DXR cell migration and invasion. (A) Wound healing assay outcomes for MG63/DXR cells at 0-, 24-, and 48-hours post-treatment with control, low (20 μM), and high (40 μM) concentrations of Ginsenoside Rh4, depicting migration inhibition. (B) Quantitative analysis of the wound healing assay from panel A, indicating Ginsenoside Rh4’s effectiveness in reducing MG63/DXR cell migration. (C) Results from Transwell assays measuring MG63/DXR cell migration and invasion post-treatment with control and 40 μM ginsenoside Rh4 at 48h, revealing reduced migratory and invasive behaviors. (D) Quantitative assessment of migration from panel C, highlighting the inhibitory effect of ginsenoside Rh4 on cell migration. (E) Quantitative assessment of invasion from panel C, demonstrating ginsenoside Rh4’s ability to diminish cell invasion.