Research Paper Volume 16, Issue 14 pp 11339—11358
PART1 facilitates tumorigenesis and inhibits ferroptosis by regulating the miR-490-3p/SLC7A11 axis in hepatocellular carcinoma
Figure 5. SLC7A11 knockdown refrained cell proliferation and facilitated ferroptosis in HCC cells. (A) The relative expression of SLC7A11 was measured by RT-qPCR in HCCLM3 and Huh7 cells transfected with siRNA-PART1.1 and -PART1.3. (B) CCK-8 assay was conducted to evaluate the proliferation of HCCLM3 and Huh7 cells transfected with siRNA-SLC7A11.1 and -SLC7A11.3. (C, D) The cell apoptosis and cell cycle were assessed by flow cytometry analysis in HCCLM3 and Huh7 cells transfected with siRNA-SLC7A11.1 and -SLC7A11.3. *p < 0.05, **p < 0.01, ***p < 0.001.