Research Paper Volume 16, Issue 14 pp 11318—11338
Consensus clustering and novel risk score model construction based on m6A methylation regulators to evaluate the prognosis and tumor immune microenvironment of early-stage lung adenocarcinoma
Figure 4. Construction of prognostic model based on m6A methylation regulators in TCGA. (A) Univariate Cox analysis screened out the m6A RNA methylation regulators that were significantly correlated with the prognosis of patients with early-stage LUAD. (B) The LASSO regression model was constructed; (C) the optimal value of the lambda penalty parameter was determined by 10-cross validation; (D) risk score distribution of early-stage LUAD. Red and blue represent high risk score and low risk score, respectively; (E) distribution of overall survival status of early-stage LUAD; (F) heat map of HNRNPC, IGF2BP1 and IGF2BP3. Red indicates above the reference channel. Blue indicates below the reference channel.