Research Paper Volume 16, Issue 13 pp 11062—11071
Sevoflurane impedes neuropathic pain by maintaining endoplasmic reticulum stress and oxidative stress homeostasis through inhibiting the activation of the PLCγ/CaMKII/IP3R signaling pathway
Figure 7. In vitro experiments verified that sevoflurane could mediate the PLCγ/CaMKII/IP3R signaling pathway to inhibit ER stress, oxidative stress and inflammatory response. (A) Protein bands of p-PLCγ, p-CaMKII, p-IP3R, GRP78, P22 and NLRP3 in each group, (B) relative protein expressions of p-PLCγ, p-CaMKII, p-IP3R, GRP78, P22 and NLRP3 in each group. Sham group vs. Model group, Model group vs. Sevoflurane group, Sevoflurane group vs. Sevoflurane + IP3R Inhibitor group, **P<0.01, N=3.