Interference with ANXA8 inhibits the malignant progression of ovarian cancer by suppressing the activation of the Wnt/β-catenin signaling pathway via UCHL5

Li Xu; Liang Wang; Yaping Gan; Jiazhi Lin; Shuting Ning; Jinjin Deng; Yingxia Ning; Weifeng Feng

doi:doi:10.18632/aging.205991

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Research Paper Volume 16, Issue 14 pp 11275—11288

Interference with ANXA8 inhibits the malignant progression of ovarian cancer by suppressing the activation of the Wnt/β-catenin signaling pathway via UCHL5

Figure 4. ANXA8 bound to UCHL5 in CAOV3 cells. (A) The expression of UCHL5 in the OC cell line was detected by RT-qPCR; (B) The expression of UCHL5 in the OC cell line was detected by western blotting. ***P<0.001 vs. HOSEpiC; (C) After interference with ANXA8, the expression of UCHL5 was detected by RT-qPCR; (D) After interference with ANXA8, the expression of UCHL5 was detected using western blotting; (E, F) The binding ability between ANXA8 and UCHL5 was verified by IP experiments. ***P<0.001 vs. shRNA-NC.