Research Paper Volume 16, Issue 13 pp 10943—10971
Unfolding the mysteries of heterogeneity from a high-resolution perspective: integration analysis of single-cell multi-omics and spatial omics revealed functionally heterogeneous cancer cells in ccRCC
Figure 7. Intercellular communication networks orchestrated by functionally heterogeneous cancer cells and other cellular identities in ccRCC TME. (A) Heatmap plot of the number of ligand-receptor pairs across disparate cell clusters. (B) Radar plot of quantitative comparisons of ligand-receptor pairs across cancer cells in disparate meta programs. (C) Dot plots of mean interaction strengths of ligand-receptor pairs between functionally heterogeneous cancer cells, with dot sizes indicating the P-value and colored by the average expression level of the receptor in cancer cells. The plot for expression levels of the receptor in functionally heterogeneous cancer cells. (D) The plot showing the expression levels of the ligand in functionally heterogeneous cancer cells.