Research Paper Volume 16, Issue 14 pp 11208—11223
Cyclin L1 participates in Adriamycin resistance and progression of osteosarcoma via PI3K/AKT-mTOR pathway
Figure 3. CCNL1 promotes migration and inhibits apoptosis of OS cells. CCNL1 expression level in HOS and 143B was examined through western blot (A) and qRT-PCR. ***P < 0.001 vs. vector (B). (C) The proliferation of control and CCNL1-overexpressed cells examined through MTT. **P < 0.01, vs. HOS plus vector; ##P < 0.01, vs. 143B plus vector. (D, E) The apoptosis rate of CCNL1-overexpressed HOS, 143B cells and the control vector group was analyzed by flow cytometry. ***P < 0.001, vs. control. (F, G) Transwell results of migration ability of HOS and 143B cells. ***P < 0.001. (Bar = 200 μm).