Research Paper Volume 16, Issue 12 pp 10563—10578

Figure 1. Scatterplot and leave-one-out analysis of iridocyclitis and glucocorticoid on the risk of developing senile cataracts. IVs indicating age-related cataract were plotted against 2 mutually independent samples showing glucocorticoid use and iridocyclitis for MR analysis and sensitivity analysis. (A) Scatter plot illustrating the association between iridocyclitis and senile cataracts; (B) show leave-one-out analysis plot of iridocylitis on senile cataracts; (C) scatter plot illustrating the association between glucocorticoid use and senile cataracts; (D) show leave-one-out analysis plot of glucocorticoid use on senile cataracts; each point in the scatter plot (A, C) represents the IV, the lines on the IVs represent confidence intervals in the vertical and horizontal directions, and the horizontal and vertical coordinates represent the effect of the IVs on exposure and outcome, respectively. The different colored lines in the figure indicate the fitting effect of different methods on MR results. Leave-One-Out sensitivity analysis (B, D). Each black point represents the estimate of iridocyclitis and glucocorticoid medication use level on senile cataracts after the corresponding single nucleotide polymorphism (SNP) was excluded. MR, Mendelian randomization; IVs, instrumental variables.