Research Paper Volume 16, Issue 12 pp 10512—10538

Figure 6. Relationship between CDKN2A expression and prognosis and treatment of colorectal cancer. (A) The Kaplan-Meier curve demonstrates a correlation between high CDKN2A expression and decreased overall survival rates in colorectal cancer patients. (B) The Kaplan-Meier curve illustrates that high CDKN2A expression is linked to reduced disease-free survival in colorectal cancer patients. (C) The association between CDKN2A and clinical pathological features, including the TNM staging and pathological stage of the tumor. (D) The differences in mutated genes between CDKN2A expression groups are shown, with red lines representing genes with increased mutation rates in the high expression group, and blue lines representing genes with increased mutation rates in the low expression group. The annotated genes are involved in DNA damage repair. The X-axis represents the genomic position coordinates, while the Y-axis represents the negative logarithm of the P-values for rate comparison. (E) Genes differentially expressed between 5-FU-S and 5-FU-R cell lines after 5-fluorouracil treatment. (F) Genes differentially expressed between 5-FU-S and 5-FU-R cell lines after 5-fluorouracil plus radiation therapy. (G) Genes differentially expressed between 5-FU-S and 5-FU-R cell lines after uracil treatment.