Research Paper Advance Articles
The crosstalk role of CDKN2A between tumor progression and cuproptosis resistance in colorectal cancer
Figure 5. Association of CDKN2A with the Wnt signaling pathway and EMT. (A) Enriched Reactome pathways for differentially expressed genes in the TCGA colorectal cancer cohort, with dark green representing pathways involving upregulated genes and light green representing pathways involving downregulated genes. (B) KEGG pathways enriched for upregulated genes in the CDKN2A high-expression group, showing upregulation of the Wnt signaling pathway. (C) Comparison of Wnt signaling pathway scores between different CDKN2A expression groups in tumor epithelium cells, ***P < 0.001, Wilcoxon test. (D) Knockdown of CDKN2A leads to decreased mRNA expression levels of Wnt signaling pathway members in CRC cell lines. *P < 0.05, **P < 0.01, ***P < 0.0001. (E) Comparison of EMT scores among different CDKN2A expression groups in tumor epithelial cells. ***P < 0.001, Wilcoxon test. (F) The scatter plot shows the correlation between the expression level of CDKN2A and EMT score in the TCGA cohort.