MATN4 as a target gene of HIF-1α promotes the proliferation and metastasis of osteosarcoma

Lu Zhang; Yujie Pan; Feng Pan; Songsong Huang; Fengyan Wang; Zhirui Zeng; Houping Chen; Xiaobin Tian

doi:doi:10.18632/aging.205941

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Research Paper Advance Articles

MATN4 as a target gene of HIF-1α promotes the proliferation and metastasis of osteosarcoma

Figure 4. Inhibition of MATN4 significantly reversed the promoting effects of hypoxia on the migration and invasion abilities of OS cells. (A) Transwell assays were used to detect the invasion ability of OS cells transfected with sh-scramble or SH-MATN4 under normoxia and hypoxia. (B) Wound healing assays were used to detect the invasion ability of OS cells transfected with sh-scramble or SH-MATN4 under normoxia and hypoxia. *, p <.05; **, p <.01.